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. 2009 Apr;133(4):375–386. doi: 10.1085/jgp.200810157

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© 2009 Mazzolini et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — The interaction between L356 and F380 is within the same subunit. Diagrams representing subunit composition of the tandem L356X_tandemWT (A, top row), the tandem L356X_tandemF380X (B, top row), and the tandem L356X+F380X_tandemWT (C, top row) in which X = C or A. Each subunit is represented by a circle, whereas the linker of 10 amino acids between two subunits of the tandem is represented by an arc (see Materials and methods). In the middle row, cGMP-activated currents in the presence of 1 mM cGMP at +60 mV in the tandem L356C_tandemWT (A, middle row), in the tandem L356C_tandemF380C (B, middle row), and in the tandem L356C+F380C_tandemWT (C, middle row). In the bottom row, cGMP-activated currents in the presence of 1 mM cGMP at +60 mV in the tandem L356A_tandemWT (A, bottom row), in the tandem L356A_tandemF380A (B, bottom row), and in the tandem L356A+F380A_tandemWT (C, bottom row).