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. 2009 Mar 16;206(3):549–559. doi: 10.1084/jem.20082394

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© 2009 Ohnmacht et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Impaired immune response in ΔDC mice. (A) Frequency of OT-II cells in the spleen after adoptive transfer and before (open bars) or 4 d after (filled bars) MVA-OVA immunization of ΔDC or control mice. Pooled results are from two separate experiments. n = 4; *, P < 0.028. (B) Transferred OT-II cells (Thy1.1⁺) are less activated (CD62L^neg) in ΔDC as compared with control mice. (C) Kinetics of expansion of K^b-OVA_257-264 pentamer-specific CD8 T cells in ΔDC mice (open circles) or controls (filled circles) after immunization with MVA-OVA. n = 3 ΔDC mice and 2 controls. Error bars show SD. (D) Dot plots are gated on CD8⁺ cells and show staining of K^b-OVA_257-264 pentamers versus CD62L. (E) Number of adult worms in the small intestine of four ΔDC mice or controls on day 10 after N. brasiliensis infection from two independent experiments. The filled circles show worm counts from individual mice. The bars show the means. (F) Frequency of CD4 T cells (CD4⁺Siglec-F⁻) and eosinophils (CD4⁻Siglec-F⁺) in dispersed total lung tissue of ΔDC mice and controls. Dot plots are representative of four mice per group.