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. 2009 Mar 16;206(3):561–576. doi: 10.1084/jem.20081886

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© 2009 Linterman et al.

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Figure 3. — Spontaneous GC and T_FH formation are corrected by loss of SAP in Roquin^san/san mice. (a) CD4⁺CXCR5⁺PD-1^high T_FH cells in unimmunized 10-wk-old Roquin^san/san and Roquin^san/san Sap^−/− mice (P = 0.0056). Representative flow cytometric contour plots are shown (right). Data are representative of four independent experiments (n = 4 per group). (b) B220⁺GL-7⁺CD95⁺ GC B cells in unimmunized 10-wk-old Roquin^san/san Sap^+/+ and Roquin^san/san Sap^−/− mice (P = 0.0007). Representative flow cytometric contour plots are shown (right). Data are representative of four independent experiments (n = 4 per group). (c) Photomicrographs of frozen spleen sections from unimmunized 6-mo-old mice of the indicated genotypes stained with IgD (brown; all panels), PNA (blue; left), TCRβ (blue; middle), and PD-1 (blue; right). Bars, 200 µm.