Figure 3.

Calsenilin (CLSN) reverses the acceleration of decay rates conferred by mutant PS1. Quantitation of mean times to decay from peak ΔF/F_o to 1/2 peak (t_1/2) for all calcium signals evoked by supramaximal Ins(1,4,5)P₃ stimulation (n = 27–32 per condition). Note that decay rates are significantly accelerated by PS1_M146V-expressing cells, whereas decay rates of wt PS1-expressing cells did not differ significantly from those of controls. *, P < 0.001 relative to controls and to cells coexpressing CLSN and PS1_M146V.