Table 1. Patient data and CRT effects according to diagnostic group.
Patient data | All (n = 109) | CHD (CRT only) (n = 71) | CHD (CRT + concurrent cardiac surgery) (n = 16) | Congenital AV block (n = 12) | DCMP (n = 10) | p Value* |
Age at CRT (years), median | 16.9 | 25.5 | 13.9 | 3.6 | 12.7 | <0.001 |
Follow-up on CRT (months), median | 7.5 | 8.8 | 4.0 | 9.5 | 2.3 | 0.099 |
Initial QRS (ms), median | 160 | 160 | 160 | 155 | 144 | 0.082 |
Initial SVEDD (z score), median | 3.3 | 2.5 | 2.6 | 3.7 | 5.5 | 0.131 |
Initial EF/FAC (%), median | 27.0 | 27.5 | 24.5 | 24.5 | 22.0 | 0.602 |
Initial SAVV regurgitation (grade), median | 1 | 1 | 0 | 1 | 2 | 0.589 |
Initial NYHA class (median) | 2.5 | 2.5 | 2.0 | 2.5 | 4.0 | 0.058 |
Change in QRS (ms), median | −40§ | −40§ | −46§ | −40§ | −15 | 0.268 |
Change in SVEDD (z score), median | −1.1§ | −1.2§ | −0.8 | −2.2¶ | −0.4 | 0.582 |
Change in EF/FAC (%), mean (SD) | +11.5 (14.3)§ | +9.9 (13.8)§ | +12.3 (17.1)¶ | +23.5 (12.2)¶ | +10.8 (11.9)% | 0.358 |
Change in SAVV regurgitation (grade), median | −1§ | 0 | 0 | −1¶ | 0 | 0.556 |
Change in NYHA class (median) | −1.0§ | −1.0§ | −1.0† | −1.0‡ | 0.0 | 0.028 |
Non-responders | 15/94 | 7/60 | 0/13 | 2/12 | 6/9 | <0.001 |
*Significance levels across diagnostic categories; significance levels inside diagnostic categories pre-CRT vs post-CRT: †p<0.01; ‡p<0.005; §p<0.001; ¶p<0.05.
AV, atrioventricular; CHD, congenital heart disease; CRT, cardiac resynchronisation therapy; DCMP, dilated cardiomyopathy; EF, ejection fraction; FAC, fractional area of change; NS, non-significant; NYHA, New York Heart Association; SAVV, systemic atrioventricular valve; SVEDD, systemic ventricular end-diastolic dimension.