Table 1.

ADAMTS-18 385-AA fragment given 2 hours before or after obstruction of right middle cerebral artery and examined 8 days after removal of obstruction

	No.	% Infarct	Postural reflex*	Rotor rod†	Transverse beam†
385AA	13	23.9 ± 4.0	1.02 ± 0.17	4.62 ± 0.58	5.97 ± 0.48
66AA+	8	43.8 ± 7.3	2.87 ± 0.13	3.23 ± 0.45	3.87 ± 0.90
Saline	14	43.0 ± 4.8	2.31 ± 0.25	3.19 ± 0.34	4.52 ± 0.46
P§		< .001	< .002	< .04	< .01

^*Higher number reflects greater neurologic damage.

^†Lower number reflects greater neurologic damage.

^§Student t test comparison of intravenous injections of saline vehicle versus 35 μg ADAMTS-18 385-AA fragment versus functionally inactive ADAMTS-18 66-AA fragment (control). Since differences were not noted between pre– and post–ADAMTS-18 385-AA fragment infusion, both groups were averaged.