Table 3.

Blood pharmacokinetic analysis of 22-20, 20-22, e-mab, and v-mab after intravenous injections in BALB/c mice

Reagent	Injected dose, nmol/kg	Cmax, pmol/mL	T½ hours	AUC0.08→∞, hours*pmol/mL	Clearance rate, mL/hr	MRT0.08→∞, hours
22-20	6.8	45.3	24.2	1379	0.0986	36.9
e-mab	6.8	39.7	52.3	2469	0.0551	77.8
20-22	6.8	61.0	37.2	1736	0.0781	53.6
v-mab	6.8	61.5	45.7	3286	0.0412	74.7