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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: J Pain. 2009 Jan 29;10(4):380–390. doi: 10.1016/j.jpain.2008.09.013

Figure 4.

Figure 4

Spatial knockdown of NR1 in the spinal cord dorsal horn (SCDH) provides protection from the establishment of mechanical allodynia 24hrs post formalin. A) Three weeks after the intraparenchymal injection of vector 6 (n =10) or MM-6 (n =9) into the right SCDH, the baseline mechanical responses to von Frey filaments are not altered. B) One hour post intraplantar injection of formalin into the right hind-paw, all three treatments were significantly different than the corresponding groups at either the preformalin or 24 hr time points (***P<0.001). At 24 hrs the vector 6 group was not different than the corresponding vector 6 pre-formalin group but was different from the both the non-vector treated and vector MM-6 groups at the 1 hr time point (**P<0.01). In all three groups of animals, the effect of formalin was bilateral causing a significant lowering of mechanical response in the left hind-paw at 1hr post formalin (*P<0.05) compared to the pre-formalin threshold.