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. Author manuscript; available in PMC: 2009 Jun 19.
Published in final edited form as: Curr Opin Colloid Interface Sci. 2007 Dec 1;12(6):285–296. doi: 10.1016/j.cocis.2007.08.014

Fig. 4.

Fig. 4

a) The left panel illustrates the potential of mean force (PMF) for an idealized two-state system where the reaction coordinate (shown as the black-and-white arrow) aligns well with the reaction coordinate. b) The right panel illustrates the PMF for a two-state system where the reaction coordinate is not well-aligned with the spectroscopic coordinate. For the PMF above the single molecule measurement would primarily report on intrastate dynamics. The intrastate dynamics would appear non-Markovian since they would depend indirectly the unknown state along the reaction coordinate.