Fig. 6.

The inset is a potential of mean force loosely adapted from [52]. The PMF is displayed as a contour plot over the two principle coordinates that best described the folding of the G-Peptide from random coil to beta-hairpin. Several meta-stable states were observed in the transition state region of the PMF in this study. These intermediates had partial alpha helix character and contributed to the non-exponentiality of the first-passage-time distribution. (Shown as dark gray FPT distribution.) When these states were split the FPT distribution for the microstates (colored FTP sub-distributions) became exponential, except at short times as expected.[53]