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. Author manuscript; available in PMC: 2010 Jun 27.
Published in final edited form as: Tetrahedron. 2009 Jun 27;65(26):5102–5109. doi: 10.1016/j.tet.2009.04.071

Table 1.

Formation of macrocycles.

graphic file with name nihms113584f19.jpg
entry R conditions vinyl JHH (Hz) product yield%
1 H toluene, 25 °C 16.2 trans-4a 36
2 Me toluene, 25 °C 16.2 trans-4b 87
3 OMe toluene, 25 °C 16.2 trans-4c 94
4 F ClCH2CH2Cl, 60 °C 9.8 cis-4d 92