Figure 1.

Comparison of automated and manual scorings of apoptosis and DNA damage markers in tumor xenografts. Automated and manual scorings for cleaved caspase-3, cleaved lamin A, cleaved poly(ADP-ribose)-polymerase1 (PARP-1), γH2AX, and terminal deoxyribonucleotidyl transferase–mediated dUTP nick end labeling (TUNEL) were compared on the selected breast cancer areas using tissue microarray (TMA) Lab software (A–C). Correlation analysis compares automated and manual assessment of c-caspase-3–positive nuclei on 10 virtual TMA cores (D). r = 0.8860; p=0.001.