Table 4.
HPV DNA detection (GP5+/GP6+) and typing (specific primers) in 55 patients with laryngeal carcinoma stratified according to histological diagnosis
| HPV positive n (%) | HPV negative n (%) | HPV6 n (%) | HPV18 n (%) | HPV31 n (%) | HPV two types n (%) | |
|---|---|---|---|---|---|---|
| LSCCS | 1 (14.3) | 9 (16.4) | — | 1 (14.3) | — | 1 (14.3)a |
| LSCCWT | 2 (28.6) | 25 (45.5) | 1 (14.3) | — | — | 1 (14.3)b |
| LSCCW | 2 (28.6) | 26 (47.3) | — | — | 1 (14.3) | 2 (28.6)c |
| Lymph nodes | 2 (28.6) | 26 (47.3) | — | — | — | |
| Total | 7 (10.8) | 48 (87.3) | 1 (14.3) | 1 (14.3) | 1 (14.3) | 4 (57.1) |
a
HPV31 and -33.
b
HPV6 and -16.
c
First patient HPV16 and -31 and second patient HPV16 and -33.
In 10 (15.4%) patients, the beta-globin gene was not amplified, indicating DNA degradation, and these patients were not considered to be HPV negative or positive. HPV, human papillomavirus.