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Importance of the Inr sequence for GABA regulation and promoter activity. (A) Sequence of the Inr and downstream flanking region. (B and C) Primary cultures of rat neocortex were transfected with either β1-P, (−5/+19)3, (−5, +19), Δ(−2/+18), Mt(−1,+2), or a promoterless vector. (B) Activity is expressed as the mean percentage of vehicle control ± SEM, n = 4. Neurons were exposed to 500 μM GABA for 48 h. (C) n = 3.
