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. 2008 Sep;38(9):2548–2556. doi: 10.1002/eji.200738106

Figure 1.

Figure 1

PGE2 closes KCa3.1 in HLMC in a consistent and reversible manner. (A) Current–voltage curve demonstrating suppression of a 1-EBIO-induced KCa3.1 current by 10−5 M PGE2 and partial reversal of the effect following removal of PGE2 (wash). (B) Suppression of KCa3.1 current measured at +40 mV by 10−5 M PGE2 (n=22 cells). (C) Shift in whole-cell current reversal potential (Vm) by 10−5 M PGE2 (n=22 cells). (D) KCa3.1 current measured at +40 mV after addition of 1-EBIO, suppression by 10−5 M PGE2 and then reversibility of suppression following removal of PGE2 (wash) (n=5 cells). (E) Whole-cell current reversal potential (Vm) after the addition of 1-EBIO, a depolarising positive shift in response to 10−5 M PGE2, and then reversibility following removal of PGE2 (wash) (n=5 cells).