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PGE2 is ineffective in the presence of the AH6809. (A) KCa3.1 current measured at +40 mV after addition of 1-EBIO, stability following addition of AH6809, and failure to suppress following subsequent addition of 10−5 M PGE2. (B) KCa3.1 current measured at +40 mV in resting cells, after addition of AH6809, and then following subsequent addition of 10−5 M PGE2 showing failure of KCa3.1 to open.
