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. 2008 Sep;38(9):2548–2556. doi: 10.1002/eji.200738106

Figure 5.

Figure 5

The effect of 10−5 M PGE2 on KCa3.1 currents elicited by anti-IgE-dependent mast cell activation. (A) A representative HLMC demonstrating the development of a KCa3.1 current following anti-IgE-dependent activation, suppression of this by 10−5 M PGE2, and reversal of the PGE2-induced suppression by the EP1/2 receptor antagonist AH6809. (B) KCa3.1 current measured at +40 mV after addition of anti-IgE, suppression by 10−5 M PGE2 and then reversibility of suppression following addition of AH6809 (n=5 cells). (C) Whole-cell current reversal potential (Vm) after the addition of anti-IgE, a depolarising positive shift in response to 10−5 M PGE2, and then reversibility following addition AH6809 (n=5 cells).