Table 1. Sequences, designations, and IC50 values of the peptides and their lipophilic conjugates.
Designation | X | Peptide sequence | Z | IC50(nM) |
N36 | H | X- SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL | 488±119 | |
AcN36 | Acetate | >2000 | ||
C8-N36 | C8- | 222±56 | ||
C12-N36 | C12- | 190±21 | ||
C16-N36 | C16- | 72±27 | ||
N36M | SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILK(δ-NHZ) | 531±48 | ||
N36M-C8 | -C8 | 354±25 | ||
N36M-C12 | -C12 | 241±89 | ||
N36M-C16 | -C16 | 159±47 |