Figure 3.

Genotypic and phenotypic progression of the composite population, adapted from ref. 19. The diversity ratio and catalytic rate constant (k_obs) were determined over multiple generations, to trace changes in both the genotypic and phenotypic character of the composite population. The diversity ratio is a measure of the sequence diversity within the population, and is defined as the number of different sequence classes divided by the number of sequenced clones. In experiment A, the selection pressure was increased by decreasing the selection time from 5 h to 5 s. In experiment B, the selection time was maintained at 5 h in every generation.