Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Jun 30;4(6):e6092. doi: 10.1371/journal.pone.0006092

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

PMC Copyright notice

(A and B) Volcano plots showing the effects of METH on striatal gene expression. Comparison of METH-treated rats to control rats revealed that METH caused changes in (A) 300 genes at 2 h after the METH injection, of which 189 were induced and 111 were repressed, and (B) 316 genes at the 4 h time-point, of which 133 were induced and 183 were repressed. The Volcano plots showing the effects of SCH23390 pre-treatment on METH-induced striatal gene expression are shown in (C) and (D). These comparisons revealed that these two groups show differences in the expression (C) of 271 genes at the 2 h time-point, the expression of 184 of which was inhibited and of 87 of which was potentiated by SCH23390 (D) of 293 genes at the 4 h time-point, the expression of 175 of which was inhibited and of 118 of which was potentiated by SCH23390. (E) The Venn diagram shows the overlap of genes that are common between the two different comparisons: M vs. C and M vs. M+S. Abbreviations are C, control; S, SCH23390; M, methamphetamine. To be identified as SCH23390-responsive, the genes must have passed the following criteria: greater or less than 1.7-fold changes at p<0.05.The 173 METH-responsive genes that were influenced by pre-treatment with SCH23390 are listed in Table S3 and the SCH23390-resistant genes are listed in Table S4.