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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Mol Genet Metab. 2009 Feb 13;97(1):65–74. doi: 10.1016/j.ymgme.2009.01.006

Table 2.

Calculated pKa values for mutated GCases

Source Taurocholate/Triton X-100
 Brain Phosphatidylserine
pK1* pK2 pK1 pK2
N370 4.9 6.7 5.4 7.2
N370D <4.5 6.2 5.1 6.8
N370S 4.9 7.2 5.3 7.0
N370E 4.7 6.2 <4.5 6.38
N370Q 5.03 6.34 4.6 6.2
E235G -------- 6.8 7.1
*

All values T S E L 0.25 pH units. Data fit to a diprotic model in Prism by least squares methods.