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. Author manuscript; available in PMC: 2009 Jun 22.
Published in final edited form as: Dev Biol. 2007 Oct 24;313(1):234–245. doi: 10.1016/j.ydbio.2007.10.014

Figure 5. Cap mesenchyme derived nephrons assume temporally-dependent deep and superfical positions in the adult kidney.

Figure 5

Cited1-CreERT2 mice were crossed to R26RLacZ reporter mice and injected with 1.5 mg of tamoxifen at times indicated. Mice were sacrificed at 6 weeks of age and lineage assessed with β-Gal staining. A, E11 injections result in recombination in a low percentage of nephrons, but cap derived cells are found in the cortex, medulla, and papilla (arrows). B/C, Injection at E13 (B) and E15 (C) results in recombination in a large proportion of nephrons, some of which extend into the papilla (arrows). D, E18 injection results in recombination in an intermediate number of nephrons, however these structures do not extend into the papilla (arrowheads). Cx–cortex, Md–medulla, Pa–papilla.