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. Author manuscript; available in PMC: 2009 Jun 22.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Jun 6;17(16):4527–4530. doi: 10.1016/j.bmcl.2007.05.099

Scheme 3.

Scheme 3

Reagents & Conditions. (a) C6H11CHO, Pd/C, MeOH, rt, 4h, 95%; (b) I2, imidazole, Ph3P, toluene, 80 °C, 1 h, 56%; (c) PCC, CH2Cl2, rt, 4h, 85%; (d) PPh3, 120 °C, 4 h, 67%; (e) THF-HMPA, BuLi, −30 °C, 2 h, 55%; (f) Et4N+F−, THF, rt, overnight, 86%; (g) Pd(OH)2, H2, EtOAc-MeOH (1:1), rt, 4h, 62%.