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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2009 May 3;238(1):64–70. doi: 10.1016/j.taap.2009.04.015

Figure 4. COX-2 specific inhibitor DuP697 attenuated LPS-induced astrocyte proliferation.

Figure 4

COX-2 specific inhibitor DuP697 was applied 1 h prior to LPS treatment in primary enriched astrocyte cultures together with insert wells with microglia. (A) The supernatant were collected 72 h after treatment and PGE2 concentration was assayed using an EIA kit. (B) Cell proliferation was assayed at 72 h after treatment using a BrdU ELISA kit. Results are mean ± S.E.M of three experiments performed in triplicate. * p <0.05, compared with control cultures; # p <0.05, compared with LPS treatment group.