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. Author manuscript; available in PMC: 2009 Jun 22.
Published in final edited form as: J Am Coll Cardiol. 2008 Jul 8;52(2):158–165. doi: 10.1016/j.jacc.2007.12.062

Figure 3. Effect of GCH1 Haplotype on Vascular Superoxide, Oxidative Stress, and Endothelial Function.

Figure 3

The presence of the X haplotype was associated with higher total superoxide (O 2−) production (A) and greater L-NAME-inhibitable delta[O2−] (B) in human saphenous veins. The X haplotype was also associated with significantly lower plasma BH4:tBio ratio (C) and higher plasma levels of oxidized low-density lipoprotein (ox-LDL) (D). In addition, the X haplotype was also associated with lower maximum vasorelaxations in response to acetylcholine (ACh) (E) in saphenous veins, although it had no impact on the vasomotor responses to sodium nitroprusside (SNP) (F).