Figure 1.

A) An ARGARRAY display [37] of categorical and survival analyses for AIDS progression in 34 Caucasian mitochondrial haplogroups. A phylogenetic tree showing the relationship between haplogroups is shown on the left [29]. Each major haplogroup was analyzed, and then successively more definitive subgroups within the haplogroups were analyzed separately. The haplogroups known to contain uncoupling SNPs are in red type in the phylogenetic tree. B) Individual SNP genotypes within the U and J Mitochondrial haplogroups. Locations of SNP in coding genes of the mitochondria are given. *=non-synonymous substitution. Significant values are shown in color (non-grey). Hazardous hazard and odds ratios are indicated by orange and red squares, while significant protection is show in green and blue. In AIDS progression Categorical analyses, 2= dichotomous categorical analysis, M=multipoint categorical analysis.

The AIDS association tests illustrated on the horizontal are non-independent. However, the hypothesis study groups: AIDS progression in MSM patients and AIDS progression in patients with hemophilia can be considered independent although tests within each hypothesis study group are related. The five associations IWX, U5a, Uk, J, and H3 did not replicate between MSM cohorts and hemophilia cohorts perhaps as a result of fewer study participants among the hemophiliacs (N=158 versus MSM N=615).