Table 1.

Recruitment and enrollment of women in clinical trial 2004 to March 2008

	n
	2004	2005	2006	2007	2008	Total	% of screened
Recruitment sources
Automatic hospital order	325	416	338	246	42	1,367	81.3
Proactive hospital search	74	38	6	0	0	118	7.0
Physician practice referral	20	16	12	33	6	87	5.2
Newspaper ad/article	2	22	44	8	1	78	4.6
Community/church referral	1	1	1	7	1	11	0.7
Self-referral	1	6	4	0	0	11	0.7
Friend referral	0	0	5	1	0	6	0.4
University Web site	…	0	1	2	0	3	0.2
Total referrals	423	499	411	298	50	1,681
Exclusions before orientation							% of exclusions
Diagnostic exclusion criteria	85	140	89	54	4	372	52.0
Medically unable	29	24	39	42	3	137	19.0
Non-English speaking	26	27	28	17	4	102	14.2
Cognitive limitation	11	10	11	3	0	35	5.0
Unable to ambulate	3	11	6	4	1	25	3.5
Psychiatric limitation	2	2	4	4	1	13	1.8
Previous study subject	0	1	10	2	0	13	1.8
AICD in last year	4	3	3	0	0	10	1.4
Deceased	3	2	1	1	0	7	1.0
Functionally illiterate	1	1	0	0	0	2	0.3
Total exclusions	164	221	191	127	13	716	42.6% of referrals
Total eligible	259	278	220	171	37	965
Nonparticipation at orientation							% of eligible
Geographically distant	38	58	36	9	1	142	14.7
Uninterested in CR	36	40	35	24	5	140	14.5
Unresponsive to telephone/letter	48	41	25	12	2	128	13.3
Referred to closer CR	…	6	32	30	14	82	8.5
Transportation difficulty	18	15	15	9	0	57	6.0
Employment restrictions	8	7	12	15	4	46	4.7
Insurance limitations	11	11	9	6	2	39	4.0
Inconvenient study protocol	20	5	3	4	1	33	3.4
Telephone disconnected	…	13	6	1	0	20	2.2
Family obligations	0	5	2	5	1	13	1.3
Other	13	0	0	0	0	13	1.4
Total nonparticipation	192	201	175	115	30	713	73.8% of eligible
Total randomized	67	77	45	56	7	252	26.2% of eligible

Abbreviations: AICD, automatic internal cardiac defibrillator; CR, cardiac rehabilitation.