Table 3.
Mean number of HER-2 and CEP17 copies per cell, copy number ratios and proportion of cells aneusomic for chromosome 17 in uterine serous papillary carcinoma (USPC) versus all other histologic subtypes of endometrial cancer.
| Parameter | Mean copy number (Standard Deviation) | Pr > Chi- Square* | |
|---|---|---|---|
| UPSC (n=28) | Other EC (n=141) | ||
| HER-2 | 3.8 (2.45) | 3.64 (6.78) | <0.001 |
| CEP17 | 2.13 (0.56) | 1.90 (0.51) | 0.04 |
| HER-2/CEP17 | 1.86 (1.33) | 1.89 (3.11) | 0.06 |
| Mean percentage of cells | |||
| Monosomic + | 33 | 39 | 0.14 |
| Polysomic ++ | 30 | 20 | 0.03 |
| Aneusomic +++ | 63 | 59 | 0.18 |
Kruskal-Wallis Test;
percentage of cells with reduction of chromosome 17 to one copy;
proportion of cells with gain of chromosome 17 to three or more than three copies per cell;
Monosomic+Polysomic.