Table 1.

Contraindications and dose adjustments for sildenafil (as well as for the other phosphodiesterase type 5 inhibitors)

Absolute contraindications Concomitant use of nitrates Medications / conditions requiring lower doses Ketoconazole Itraconazole Erythromycin, Clarithromycin HIV protease inhibitors (ritonavir, saquinavir) Severe kidney dysfunction Severe hepatic dysfunction Medications / conditions requiring higher doses Rifampin Phenobarbital Phenytoin Carbamazepine