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. Author manuscript; available in PMC: 2009 Jun 22.
Published in final edited form as: AIDS Rev. 2008;10(3):131–142.

Figure 6.

Figure 6

In vitro selection of resistant HIV from wild-type in the presence of amprenavir, lopinavir, nelfinavir, or darunavir (TMC114) in sequential passage experiments. Each passage represents 3–4 days with passage 75 representing a total of 260 days. Enlarged symbols indicate genotypes of viruses selected at defined times and list all genotypic changes from the original HIV-1 LAI strain. Curves are normalized and starting concentrations were 10, 20, 100 and 100 nM for darunavir (TMC114), lopinavir, amprenavir and nelfinavir respectively (reproduced with permission51).