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Effects of volatile anesthetics on voltage-dependence of Nav1.4 activation. Normalized conductance data (mean±SEM) were fitted to a Boltzmann equation to yield voltage of 50% maximal activation (V1/2a) and slope factor. Holding potential was −120 mV (n=5–12). There were no significant shifts in V1/2a or slope factor (P > 0.05 by t-test). See Fig. 2 legend for abbreviations.
