Table 1.
Odds ratios for diabetes complications by anti-HSP27 values in the nested case-control study within the EURODIAB study
| Odds ratio(95% CI)* | Odds ratio(95% CI)† | Odds ratio(95% CI)‡ | |
|---|---|---|---|
| All complications | |||
| Log anti-HSP27 | 1.07 (0.84–1.36) | 1.00 (0.76–1.30) | 1.12 (0.80–1.58) |
| Anti-HSP27 (AU/ml) <11.33 | 1.00 | 1.00 | 1.00 |
| 11.33–21.27 | 1.20 (0.72–2.02) | 1.05 (0.59–1.89) | 1.56 (0.75–3.28) |
| 21.28–32.68 | 0.87 (0.51–1.48) | 0.57 (0.31–1.05) | 0.59 (0.28–1.28) |
| >32.68 | 1.25 (0.75–2.09) | 1.24 (0.69–2.23) | 1.65 (0.80–3.43) |
| P for linear trend | 0.65 | 0.87 | 0.56 |
| DSP | |||
| Log anti-HSP27 | 1.10 (0.84–1.43) | 0.97 (0.71–1.33) | 0.94 (0.62–1.41) |
| Anti-HSP27 (AU/ml) <11.33 | 1.00 | 1.00 | 1.00 |
| 11.33–21.27 | 1.26 (0.71–2.24) | 0.98 (0.49–1.94) | 1.76 (0.70–4.40) |
| 21.28–32.68 | 0.93 (0.51–1.70) | 0.56 (0.27–1.15) | 0.45 (0.18–1.21) |
| >32.68 | 1.26 (0.71–2.24) | 1.16 (0.59–2.30) | 1.17 (0.48–2.87) |
| P for linear trend | 0.66 | 0.98 | 0.63 |
| Micro-/macroalbuminuria | |||
| Log anti-HSP27 | 1.02 (0.78–1.34) | 0.98 (0.71–1.35) | 0.96 (0.60–1.54) |
| Anti-HSP27 (AU/ml) <11.33 | 1.00 | 1.00 | 1.00 |
| 11.33–21.27 | 1.16 (0.66–2.05) | 1.13 (0.58–2.23) | 2.25 (0.80–6.34) |
| 21.28–32.68 | 0.90 (0.50–1.63) | 0.66 (0.33–1.34) | 0.59 (0.20–1.66) |
| >32.68 | 1.08 (0.61–1.92) | 1.30 (0.65–2.59) | 1.30 (0.47–3.62) |
| P for linear trend | 0.99 | 0.82 | 0.79 |
| Retinopathy | |||
| Log anti-HSP27 | 1.08 (0.83–1.38) | 1.03 (0.76–1.39) | 1.11 (0.74–1.67) |
| Anti-HSP27 (AU/ml) <11.33 | 1.00 | 1.00 | 1.00 |
| 11.33–21.27 | 1.28 (0.75–2.18) | 1.37 (0.71–2.63) | 2.28 (0.93–5.60) |
| 21.28–32.68 | 0.97 (0.56–1.68) | 0.66 (0.33–1.30) | 0.69 (0.28–1.70) |
| >32.68 | 1.25 (0.73–2.13) | 1.50 (0.78–2.90) | 2.09 (0.84–5.19) |
| P for linear trend | 0.66 | 0.60 | 0.49 |
| Cardiovascular disease | |||
| Log anti-HSP27 | 1.47 (1.09–1.99) | 1.33 (0.93–1.90) | 1.33 (0.85–2.07) |
| Anti-HSP27 (AU/ml) <11.33 | 1.00 | 1.00 | 1.00 |
| 11.33–21.27 | 1.72 (0.88–3.40) | 1.56 (0.70–3.43) | 1.72 (0.64–4.62) |
| 21.28–32.68 | 1.50 (0.75–2.99) | 0.76 (0.33–1.77) | 0.69 (0.24–1.90) |
| >32.68 | 2.41 (1.25–4.64) | 2.43 (1.11–5.43) | 2.35 (0.90–6.10) |
| P for linear trend | 0.02 | 0.09 | 0.21 |
*Unadjusted.
†Adjusted for age and diabetes duration.
‡Adjusted for age, diabetes duration, hypertension, A1C, smoking, and log tumor necrosis factor-α.