Table 2.

Most frequently reported adverse events

	Once weekly				Once every 2 weeks
	Placebo	5 mg	10 mg	20 mg	10 mg	20 mg
n	49*	50*	49*	50*	50*	49*
Nausea	3 (6)	11 (22)	12 (24)	26 (52)	16 (32)	20 (10)
Diarrhea	4 (8)	4 (8)	5 (10)	5 (10)	8 (16)	9 (18)
Vomiting	2 (4)	2 (4)	2 (4)	11 (22)	6 (12)	12 (24)
Headache	3 (6)	1 (2)	3 (6)	6 (12)	7 (14)	6 (12)
Decreased appetite	—	—	5 (10)	3 (6)	4 (8)	3 (6)
Dyspepsia	—	—	4 (8)	6 (12)	3 (6)	2 (4)
Abdominal distension	—	—	2 (4)	2 (4)	3 (6)	6 (12)

Data are n (%).

*All patients who received at least one dose of study drug treatment (n = 297) were included in the safety database.