Table 1.

Neuroseverity Scoring.

Motor	Score	Scoring	Protocol	Sensory	Score	Scoring	Protocol
Spontaneous Activity	1	Does not rise up	Place mouse in empty cage and observe	Body Proprioception	1	No reaction	Push mouse from side of neck with blunt cotton swab
	2	Does not approach all cage sides			2	Slowed head turning
	3	Normal exploration			3	Normal
Motor	1	Minimal movement of one side	Hold mouse by tail and observe limb extension	Vibrissae	1	No reaction	From behind touch whiskers with elongated cotton swab
	2	Abnormal walking. Mild weakness			2	Slowed reaction
	3	Normal symmetry			3	Normal
Climbing	1	Hang for seconds & falls	Place mouse on mesh and flip upside down	Tactile Response	1	No reaction	Place mouse on mesh & touch palmar area of forepaw with sharp needle
	2	Hangs, but cannot displace mesh			2	Slowed reaction
	3	Hangs & displaces mesh			3	Normal
Balance & Coordination	1	Holds but falls	Place mouse sideways on 2 cm diameter pole
	2	Holds, but unable to walk
	3	Holds & walk