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. Author manuscript; available in PMC: 2009 Jun 22.
Published in final edited form as: Cell Metab. 2007 Sep;6(3):229–235. doi: 10.1016/j.cmet.2007.07.010

Fig. 4.

Fig. 4

Control islets treated with ScTx-1 show similar bursting to untreated Kv2.1 islets. (A) Control islet electrical activity recorded in 14mM glucose and treated with 100nM ScTx-1, black bar. Insets show islet action potentials expanded during 14mM glucose alone or in combination with 100nM ScTx treatment. (B) Kv2.1 islet electrical activity recorded in 14mM glucose and treated with 100nM ScTx-1, black bar. Insets show islet action potentials expanded during 14mM glucose alone or in combination with 100nM ScTx treatment. (C–F) Representative fast acquisition calcium traces recorded with mouse islets loaded with Fluo-4 and incubated with 200uM Tolbutamide in 2mM glucose from control (C) and Kv2.1−/− (D) animals and from the same control (E) and Kv2.1−/− (F) islet four minutes post 25nM ScTx-1.