Table IV.

Status of evaluation for stillbirth

Generally accepted tests:

Fetal autopsy

Placental evaluation

Karyotype

Indirect Coombs’

Serologic test for syphilis

Screen for fetal-maternal hemorrhage (Kliehauer-Betke or other)

Toxicology screen

Thorough medical and obstetric history

Parvovirus serology

Useful in some cases:

Lupus anticoagulant screen

Anticardiolipin antibodies

Factor V Leiden mutation

Prothrombin G20210A mutation

Screen for protein C, protein S, and antithrombin III deficiency

Uncertain utility:

TSH

Glycohemoglobin

TORCH titers

Placental cultures

Testing for other thrombophilias

Developing technology:

Comparative genomic hybridization

Testing for single gene mutations

Testing for confined placental mosaicism

Nucleic acid based testing for infection