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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Biochem Pharmacol. 2008 Oct 1;77(4):536–546. doi: 10.1016/j.bcp.2008.09.031

Figure 1. AhR signaling alters cell-cell and cell-matrix interactions.

Figure 1

Activation of the AhR pathway alters cellular adhesion in a variety of model systems. (1) AhR pathway alters the expression of ECM proteins, including types I and IV collagen and fibronectin in fetal heart and marmoset myocardium and thymocytes (17–20). (2) Expression of several integrin subtypes, including the β7 subtype is altered following AhR signaling in cytotoxic T-cells (22), thymic epithelial cells (23), macrophages (24), T-lymphocytes (25) and human amniotic epithelial cells (26). (3) Focal adhesion kinase (FAK) phosphorylation in HUVECs (29). (4) Over-expression of β-catenin results in increased AhR expression in prostate cancer cell lines (36). (5) Expression of T-cadherin is decreased following TCDD exposure in smooth muscle cells in culture and murine fetal hearts (19,32). (6) AhR-activation results in the loss of γ-catenin associated with the adherence complex in rat liver epithelial cells (33).