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. 2009 Apr 28;58(7):1672–1681. doi: 10.2337/db08-0183

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Decreased proliferation of MMCs in Col8a1⁻/Col8a2⁻ MMCs. Thymidine incorporation by Col8a1⁻/Col8a2⁻ MMCs was significantly attenuated compared with that in wild-type controls (after glucose [A] and PDGF-BB stimulation [C]). Cell proliferation was also assessed by cell counts in the presence or absence of high glucose (B) or PDGF-BB (D). E–H: Transfection of Col8A1 reversed the phenotype. I: Increased mannose concentrations had no impact upon proliferation. J: Further, compared with the wild type, Col8a1⁻/Col8a2⁻ cells had a lower pp42/pp44 level at the resting state and after stimulation with PDGF-BB in Western blots. K: p27^Kip1 levels were increased in Col8a1⁻/Col8a2⁻ MMCs, and stimulation with PDGF-BB had no further effect. *P < 0.01 vs. wild-type MMC. Bars represent SE. CON, control; KO, knockout; WT, wild-type.