Table 4.

Hydrophobicity values (log D) of drugs at pH 5.2 [30], their volume, surface area and number of positive charges.

drug	logD5.2	Vol(Å3) (base)	surface area (Å2) (base)	protons (positive charges)
CQ	-3.44	1010	606	2
DCQ	-4.61	910	555	2
AQ	-1.06	996	568	2
DAQ	-2.54	930	554	2
VP	0.59	1340	734	1