Table 5.
Changes in physicochemical parameters seen in mutations associated with CQ-resistance in lines of P. falciparum from field and laboratory*.
| RESIDUE | mutants | Δ sc charge res-sens | Δ EIS res-sens | Δ SCV Å3 res/sens |
| CYS 72 | SER | 0 | -0.30 | 0.834 |
| MET 74 | ILE | 0 | 0.47 | 0.957 |
| ASN 75 | GLU | -1 | 0.02 | 1.111 |
| LYS 76 | THR ILE* ASN* | -1 -1 -1 | 0.92 1.83 0.46 | 0.652 0.855 0.699 |
| HIS 97 | GLN | -1 | -0.29 | 0.921 |
| ALA 220 | SER | 0 | -0.51 | 1.170 |
| GLN 271 | GLU | -1 | 0.07 | 0.923 |
| ASN 326 | SER ASP | 0 -1 | 0.38 -0.08 | 0.714 0.907 |
| ILE 356 | THR LEU | 0 0 | -0.91 -0.20 | 0.761 1.007 |
| ARG 371 | ILE THR | -1 -1 | 2.53 1.62 | 0.744 0.566 |
| MEAN (± S.E.) | -0.60 (0.13) | 0.40 (0.25) | 0.86 (0.04) |