Table 7.
For 5 or 6 transfectants of varying sensitivity, the Pearson negative correlations of IC50 value and physicochemical characteristics (R2 values) are shown, and significant results (P ≤ 0.05) on 2-tailed analyses are asterisked.
drug | ratio R/S | EIS 72-76 | EIS 72-371 | SCV 72-76 | SCV 72-371 | CH 72-76 | CH 72-371 |
CQ | 6.4 | 0.35 | 0.30 | 0.77* | 0.95* | 0.80* | 0.80* |
DCQ | 31.4 | 0.28 | 0.26 | 0.45 | 0.93* | 0.75* | 0.75* |
AQ | 2.0 | 0.17 | 0.08 | 0.76* | 0.47 | 0.41 | 0.41 |
DAQ | 1.9 | 0.01 | 0.01 | 0.98* | 0.34 | 0.10 | 0.10 |
CQ-VE | 4.9 | 0.04 | 0.01 | 0.98* | 0.53 | 0.32 | 0.32 |