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. 2009 Apr 28;58(7):1585–1594. doi: 10.2337/db09-0112

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© 2009 by the American Diabetes Association.

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FIG. 6. — A: Porcine insulin levels in the serum of C57BL mice transplanted with E42 pancreas and treated with costimulatory blockade agents (anti-LFA1, anti-CD48, and ±CTLA4-Ig), FTY720, with (◇) or without (○) debulking, at different time points after transplantation. Treatment with costimulatory antibodies was stopped at 3 months posttransplant, and graft maintenance was continued twice weekly only with FTY720. Insulin levels in the serum of NOD-SCID mice transplanted with E42 pancreas served as a positive control (♦). The inset demonstrates average pig insulin levels in transplanted mice over a course of 6 months. No statistical difference could be found between the tested groups. B: Porcine insulin levels in the serum of C57BL mice transplanted with E42 pancreas and treated with costimulatory blockade agents with or without debulking at different time points after FTY720 withdrawal. Data are presented as means ± SE.