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. 2009 Apr 28;58(7):1616–1624. doi: 10.2337/db08-1787

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — Leptin induces membrane hyperpolarization and inhibition of electrical activity. A: Recording of membrane potential in whole-cell configuration in αTC1-9 cells. With 0.5 mmol/l glucose, characteristic action potentials originated from a membrane potential of −39.9 ± 0.2 mV (n = 8). The application of leptin (6.25 nmol/l) induced hyperpolarization (21.1 ± 1.1 mV) and suppression of electrical activity. Removal of leptin allowed for a depolarization and recovery of electrical activity. Lept, leptin. B: Expanded records from A of different significant instants (indicated by numbers). C: With 0.5 mmol/l glucose, an intense electrical activity was recorded in mouse α-cells. Leptin (6.25 nmol/l) hyperpolarized these cells from −37.3 ± 0.6 mV to −60.6 ± 0.4 mV (n = 3) and decreased electrical activity. Lept, leptin. D: Expanded records from C of different significant instants (indicated by numbers).