FIG. 7.

Treatment of obesity with butyrate. Obesity was induced in C57BL/6J mice fed a high-fat diet for 16 weeks (21 weeks in age). The obese mice were then treated with butyrate through food supplementation for 5 weeks. A: Body weight (BW). Body weight was shown at the beginning and end of the 5-week butyrate treatment. B: Fat content. Fat content was determined in the body using nuclear magnetic resonance at the end of the 5-week treatment with butyrate. C: Intraperitoneal insulin tolerance. At the end of 5 weeks, intraperitoneal insulin tolerance testing was performed after a 4-h fast. D: HOMA-IR. Values are the means ± SE (n = 8 in each group). *P < 0.05.