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Mean glucose infusion rates during the hyperinsulinemic-euglycemic clamp after 12-week treatment with 60% high-fat diet (HFD) in wild-type (WT) rats (n = 5), HIP rats (n = 6), HIP rats treated with sitagliptin (HIP+SIT; n = 7), HIP rats treated with metformin (HIP+MET; n = 6), and HIP rats treated with combination therapy (HIP+SIT+MET; n = 6). Data are means ± SE.
