Skip to main content
. 2009 Apr 14;58(7):1499–1508. doi: 10.2337/db08-1571

FIG. 7.

FIG. 7.

Fasting hypoglycemia and deficient gluconeogenesis in LH mice fed a high-fat diet. A: Blood glucose levels in fed, fasted (6 or 16 h), or refed (fasted overnight and refed 2 h) wild-type (WT) or LH mice maintained on a high-fat diet for 6 weeks. Data are the means ± SE (n = 4–14). B: Hepatic mRNA levels in high-fat diet–fed wild-type and LH mice after a 24-h fast. Data are the means ± SE (n = 9, expressed relative to wild-type levels). C: Pyruvate tolerance test. Blood glucose levels were measured in 16-week high-fat diet–fed wild-type or LH mice after an overnight fast (time 0) and at the indicated times after an intraperitoneal injection of pyruvate (pyruvate tolerance test). Values represent the means ± SEM (n = 10), P < 0.01 by two-way ANOVA, indicating a significance difference between wild-type versus LH curves. *P < 0.05; ***P < 0.001.