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. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: Neuroscience. 2009 Mar 29;161(3):718–733. doi: 10.1016/j.neuroscience.2009.03.057

Figure 1.

Figure 1

Pharmacological inactivation of the VP blocks feeding potentiated by NAcc DAMGO, but also reduces baseline consumption. (A) Consumption of high fat chow (mean ± SEM) was elevated by NAcc DAMGO relative to control. Infusion of the GABA agonist muscimol blocked this effect, but also had strong effects on baseline levels of consumption, which were significantly reduced. NAcc DAMGO concentration, 250 ng/μl; VP muscimol concentration, 100 ng/μl. Asterisks indicated significant posthoc differences (P<0.001) from control (saline in NAcc and VP). (B) Timeline of drug effects. Shaded bar shows high fat chow consumption in the first hour; open bars show consumption in the second hour. N = 14 rats for data in Figures 1–2.