Table 2.
Quantification of human serum proteins binding to lipid-polymer hybrid NPs with a mixture of carboxyl and methoxyl surface groups (NP-COOH/OCH3). The numbers of 75/25, 50/50 and 25/75 represent the molar ratios of COOH/OCH3.
| Human serum proteins | 75/25 | 50/50 | 25/75 |
|---|---|---|---|
| Amount of protein bound | |||
| Factor H | 0.73 | 1 | 0.91 |
| Complement component C6 precursor | 0.72 | 1 | 0.85 |
| Complement C1r subcomponent precursor | 0.70 | 1 | 0.80 |
| C3b β chain | 0.80 | 1 | 0.71 |
| Complement component C8α chain precursor | 0.68 | 1 | 0.95 |
| Apolipoprotein IV | 0.85 | 1 | 0.83 |
| Apolipoprotein E | 0.69 | 1 | 0.80 |
| Apolipoprotein AI | 1.20 | 1 | 0.95 |
| Serum amyloid A-4 protein precursor | - | 1 | - |
| Apolipoprotein C-III | 0.77 | 1 | 0.86 |