Table 3.
Quantification of human serum proteins binding to lipid-polymer hybrid NPs with a mixture of carboxyl and amine surface groups (NP-COOH/NH2). The numbers of 75/25, 50/50 and 25/75 represent the molar ratios of COOH/NH2.
| Human serum proteins | 75/25 | 50/50 | 25/75 |
|---|---|---|---|
| Amount of protein bound | |||
| Factor H | 0.82 | 1 | 1 |
| Complement component C6 precursor | 0.72 | 1 | 0.87 |
| Complement C1r subcomponent precursor | 0.79 | 1 | 1 |
| C3b β chain | 0.58 | 1 | 0.98 |
| Complement component C8α chain precursor | 0.72 | 1 | 1.04 |
| Apolipoprotein IV | 0.66 | 1 | 0.83 |
| Apolipoprotein E | 0.78 | 1 | 1.21 |
| Apolipoprotein AI | 2.08 | 1 | 3.71 |
| Serum amyloid A-4 protein precursor | - | 1 | - |
| Apolipoprotein C-III | 0.85 | 1 | 0.96 |