Table 4.
Quantification of human serum proteins binding to lipid-polymer hybrid NPs with a mixture of amine and methoxyl surface groups (NP-NH2/OCH3). The numbers of 75/25, 50/50 and 25/75 represent the molar ratios of NH2/OCH3.
| Human serum proteins | 75/25 | 50/50 | 25/75 |
|---|---|---|---|
| Amount of protein bound | |||
| Factor H | 0.73 | 1 | 0.80 |
| Complement component C6 precursor | 0.53 | 1 | 0.80 |
| Complement C1r subcomponent precursor | 0.92 | 1 | 0.87 |
| C3b β chain | 0.48 | 1 | 0.91 |
| Complement component C8α chain precursor | 0.47 | 1 | 0.76 |
| Apolipoprotein IV | 0.69 | 1 | 1.00 |
| Apolipoprotein E | 0.48 | 1 | 0.93 |
| Apolipoprotein AI | 0.42 | 1 | 0.92 |
| Serum amyloid A-4 protein precursor | 1.16 | 1 | 1.21 |
| Apolipoprotein C-III | 0.59 | 1 | 0.74 |